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KMID : 0380020090240050469
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Korean Journal of Biotechnology and Bioengineering
2009 Volume.24 No. 5 p.469 ~ p.476
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Antioxidant Activity of the Salt Marsh Plant Corydalis heterocarpa
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Kim You-Ah
Lee Jung-Im
Lee Jin-hyeok
Kong Chang-Suk
Nam Tak-Jeong
Seo Young-Wan
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Abstract
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The antioxidant activities of two crude extracts ( and MeOH) and their solvent fractions (n-hexane, 85% aq. MeOH, n-BuOH, and fractions) from Corydalis heterocarpa were determined by evaluating authentic and generated from SIN-1 (3-morpholinsydnonimine) in vitro as well as by measuring the degree of occurrence of intracellular reactive oxygen species (ROS) and nitric oxide (NO). Scavenging activities of solvent fractions on authentic increased in the order of n-BuOH > 85% aq. MeOH > > n-hexane fractions, while those on generated from SIN-1 increased in the order of n-BuOH > 85% aq. MeOH > > n-hexane fractions. In addition, all solvent fractions effectively inhibited the intracellular ROS and NO levels. The n-BuOH fraction especially exhibited the strongest ROS scavenging effect. Further purification of n-BuOH fraction led to the isolation of cnidimoside A, which presented the potent ROS scavenging effect at . From these results, extracts of C. heterocarpa and its component, cnidimoside A, were predicted to be potentially useful as ingredients for protecting against oxidation.
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KEYWORD
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Corydalis heterocarpa, cnidimoside A, nitric oxide, reactive oxygen species, peroxynitrite
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